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Aug 6, 2025 · This allows the cancer to grow more quickly or spread faster. There are few treatment options for patients with advanced or metastatic solid tumors that express HER2. This clinical trial uses an experimental drug called disitamab vedotin (DV). Disitamab vedotin is a type of antibody drug conjugate or ADC.
Treating metastatic breast cancer can be difficult, as it often requires a combination of therapies and ongoing adjustments to treatment plans. Talzenna has been approved for use in patients with HER2-negative, locally advanced or metastatic breast cancer who carry the BRCA1 or …
This Phase III, randomized, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus everolimus compared with the physician's choice of endocrine therapy plus everolimus in participants with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer who have had previous …
The medication, olaparib, was designed to block an enzyme that cancer cells need to repair their DNA. It had proven especially effective against ovarian cancer in women with mutations of the BRCA gene and its use was later expanded to treat metastatic breast cancer patients like Cortez, who also carries the BRCA mutation.
Aug 9, 2025 · The reason for this study is to see if the study drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in participants with advanced or metastatic breast cancer or endometrial cancer.
Parajuli Stephany Ruiz UCI 21-212: A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1 Antibody drug conjugate
While the terms “advanced” and “metastatic” are related, they have different meanings when talking about a cancer diagnosis. Some people may use “advanced” to describe metastatic cancer, while others might use it to describe cancer that is locally advanced but hasn’t spread to other distant parts of the body. These terms can have different implications for treatment and …
-No prior chemotherapy for advanced or metastatic breast cancer. Subjects who have received chemotherapy in the neo-adjuvant or adjuvant setting are eligible, as long as they have had a disease-free interval -Life expectancy at least 12 weeks at screening
Oct 17, 2024 · Beamion BCGC-1: A Phase Ib Dose Escalation and Phase II Dose Optimization, Randomized, Open-Label, Multicenter Trial of Oral Zongertinib (BI 1810631) in Combination with Intravenous Trastuzumab Deruxtecan (T-DXd) or in Combination with Intravenous Trastuzumab Emtansine (T-DM1) for Treatment of Patients with Advanced HER2+ Metastatic Breast Cancer …
Systemic (drug) treatments for stage IV breast cancer Treatment often continues until the cancer starts growing again or until side effects become unacceptable. If this happens, other drugs might be tried. The types of drugs used for stage IV breast cancer depend on the hormone receptor status, the HER2 status of the cancer, and sometimes gene mutations that might be found. …
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